Physicians and scientists at RCEMS are engaged in cutting-edge research of how and why physical activity and sleep are essential to health.
ONGOING PROJECTS INCLUDE:
Molecular Transducers of Physical Activity Consortium (MoTrPAC) Pediatric Clinical Center.
MoTrPAC is the largest NIH-funded study of physical activity to date, with a budget of approximately $250 million. Our mission is to understand how physical activity improves health by uncovering the molecular changes that occur in response to exercise. Radom-Aizik PhD & Cooper MD, lead researchers.
Interacting mechanisms of sleep and endurance exercise in pediatrics (iSLEEP): Implications for health in the growing child.
Ariel Neikrug PhD and Ruth Benca, lead researchers.
Revamping Exercise Assessments in Child’s Health (Project REACH)
Transforming Exercise Testing and Physical Activity Assessment in Children: New Approaches to Advance Clinical Translational Research in Child Health. Cooper & Radom-Aizik lead researchers.
The Pro-Inflammatory Effects of Acute Exercise in Children with Sickle Cell Anemia
The goal of this project is to determine the influence of exercise intensity on the acute inflammatory response to exercise in children with sickle cell anemia. Radom-Aizik lead researcher in UCI site, in collaboration with Robert Liem, MD, MS Principal investigator. Director, Comprehensive Sickle Cell Program. Attending Physician, Center for Cancer & Blood Disorders, Ann & Robert H. Lurie Children’s Hospital of Chicago.
Applying New Analytic Approaches to Transforming How Physicians Gauge Fitness in Kids.
Dan Cooper MD, Ronen Bar-Yoseph MD, Shlomit Radom-Aizik PhD in collaboration with Donald E. Brown, Senior Associate Dean for Research and Quantitative Foundation, Distinguished Professor in Data Science, Virginia University.
The Impact of Chest Binders on Exercise Performance and Breathing Patterns During Exercise
The aim of this pilot study is to evaluate the effect of chest binders on exercise performance and breathing patterns. The data collected from this study will contribute to the development of evidence-based guidelines for chest binding in sport aiming to mitigate severe adverse consequences and address health disparities within our LGBTQIA+ community. Radom-Aizik PhD and Irie Padua MD, lead researchers. Laura San Giacomo: Bio 199 Excellence in Research Student.
ADDITIONAL SELECTED ONGOING AND PAST COLLABORATIONS
Flying to Space, NASA 70-Day Bed-Rest Study Genomic Analysis
Cotter JA, Plaza-Florido A, Adams GR, Haddad F, Scott JM, Everett M, Ploutz-Snyder L, Radom-Aizik S. Exercise Training Attenuates the Muscle Mitochondria Genomic Response to Bed Rest. Med Sci Sports Exerc. 2024 Apr 23. PMID: 38650118
Exercise and the Bone
N Dror 1, J Carbone, F Haddad, B Falk, P Klentrou, S Radom-Aizik. Sclerostin and bone turnover markers response to cycling and running at the same moderate-to-vigorous exercise intensity in healthy men. J Endocrinol Invest. J Endocrinol Invest 2022 Feb;45(2):391-397. PMID: 34390461
https://link.springer.com/article/10.1007/s40618-021-01659-5
A novel subcutaneous lactate monitor to improve treatment in clinical conditions
Dror N, Weidling J, White S, Ortenzio F, Shreim S, Keating MT, Pham H, Radom-Aizik S, Botvinick E. Clinical evaluation of a novel subcutaneous lactate monitor. J Clin Monit Comput 2022 Apr;36(2):537-543. PMID: 33837904
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536260
iXercise: an immersive exergaming platform for re-habilitation targeting special needs children:
Radom-Aizik in collaboration with Prof. Magda El Zarki, Director of the Inst. of Virtual Environments and Computer Games, Information and Computer Sciences, University of California, Irvine.
The effects of a physical exercise intervention on anxiety in underserved children with ASD.
Lead Researcher: Jean Gehricke, Ph.D. The Center for Autism & Neurodevelopmental Disorders
Exercise training in adults with Pompe disease: the effects on pain, fatigue, and functioning.
Lead Researcher: Virginia Kimonis, MD, UCI Division of Genetics and Genomic Medicine, Dept. of Pediatrics.
SELECTED LIST OF COMPLETED PROJECTS
School-based exercise training program designed to improve asthma in children in an inner-city neighborhood.
Lead researcher: Kim Lu, MD (Mentors: Shlomit Radom-Aizik PhD & Dan Cooper MD).
Tele-exercise program for improving fitness in children with cystic fibrosis.
Lead researcher: Jen Jen Chen, MD (Mentors: Shlomit Radom-Aizik PhD & Dan Cooper MD).
The effect of exercise on the immune system genomic and epigenetic responses in children who have survived acute lymphoblastic leukemia (ALL).
Lead researcher: Shlomit Radom-Aizik, PhD. In collaboration with the Hyundai Institute at CHOC Children’s.
The effects of therapeutic dance on the body and mind of children with cerebral palsy.
Lead researcher: Kimberley D. Lakes, PhD. In collaboration with Children’s Cerebral Palsy Movement, UCI Claire Trevor School of the Arts, CHOC Children’s Orthopaedic Institute and Chapman University.
Project BEGIN: Body Composition, Exercise, and Growth in Newborns. An assisted exercise research program to help premature babies strengthen bones and muscles.
Lead researcher: Dan M. Cooper, MD.
Inflammation and physical activity during critical periods of development.
Lead researcher: Gregory R. Adams, PhD.
The impact of caregivers’ attitudes about exercise on child health.
Lead researchers: Candice Taylor Lucas, MD and Kimberley D. Lakes.
The GREEN Project: Getting Residence Engaged in Exercise and Nutrition. Community Based Participatory Research (CBPR) brings best education practices to the community that will assist in improving community health.
Lead Researcher: Frank Zaldivar PhD. In collaboration with the UC Irvine Health PRIME-LC medical and UC Irvine undergraduate students from the schools of public health and biological sciences.
Impact of exercise training on children with neural tube defects: an exploratory study
Lead Researchers: Shlomit Radom-Aizik PhD, Dan M Cooper and Dr. Kimberly BeDell MD, Medical Director, Pediatric Rehabilitation at Miller Children’s Hospital Long Beach. In collaboration with Melissa D’Eloia, Ph.D, CTRS, California State University Long Beach, Department of Recreation and Leisure Studies CSU Long Beach, and Robert Arnhold, Ph.D, Coordinator Adapted Physical Activity Program and director of the Center on Disability and Health, Slippery Rock University. (please create a link to the movie).
The effect of an Ironman Triathlon on the immune system genomic response.
Lead Researcher: Shlomit Radom-Aizik PhD. In collaboration with the University of Connecticut, Storrs.