Research Center for Exercise Medicine and Sleep (RCEMS)

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Publications

View selected publications about the research we have conducted at the Research Center for Exercise Medicine and Sleep/Pediatric Exercise & Genomics Research Center:

  •  MoTrPAC Study Group; Lead Analysts; MoTrPAC Study Group. Temporal dynamics of the multi-omic response to endurance exercise training. Nature. 629(8010):174-183, 2024.
  • Nikolai G. Vetr, Nicole R. Gay, MoTrPAC Study Group, and Stephen B. Montgomery. The impact of exercise on gene regulation in association with complex trait genetics. Nat Commun. 15: 3346, 2024.
  • Cotter JA, Plaza-Florido A, Adams GR, Haddad F, Scott JM, Everett M, Ploutz-Snyder L, Radom-Aizik S. Exercise Training Attenuates the Muscle Mitochondria Genomic Response to Bed Rest. Med Sci Sports Exerc. 2024.
  • Abel Plaza-Florido, Robert I Liem, Fadia Haddad, Shlomit Radom-Aizik. Whole-blood transcriptome analysis reveals distinct gene expression signatures in paediatric patients with sickle cell anaemia before and after exercise. Br J Haematol. 2024.
  • Abel Plaza-Florido, Alejandro Lucia, Shlomit Radom-Aizik, Carmen Fiuza-Luces. Anticancer effects of exercise: Insights from single-cell analysis. J Sport Health Sci. 2024.
  • Einat Kodesh, Pearl Law, Fadia Haddad, Annamarie Stehli, and Shlomit Radom-Aizik. Leukocyte and Lactate Responses to Different Modes of Exercise at the Same Target Heart Rate. European Journal of Sport Science. 24(5):606–13, 2024.
  • Ivy Y. Chen, Shlomit Radom-Aizik, Annamarie Stehli, Jake Palmer, Kitty K. Lui, Miranda G. Chappel-Farley, Abhishek Dave, Daniel Gealer, Alexandra Lim, Bryce A. Mander, Ruth M. Benca, Ariel B. Neikrug. Cardiorespiratory Fitness, Circadian Rhythms, and Sleep Regularity in Adolescents. J Appl Physiol (1985). 2023.
  • Angelina Lo1, Lea Ann Lowery, Karen Kuhlthau, Robert A. Parker, James Chan, Fadia Haddad, Shlomit Radom-Aizik, Jean-G. Gehricke. Effects of physical exercise, LEGO, and Minecraft activities on anxiety in underserved children with autism: Study design and methodological strategies. MethodsX. 2023
  • Plaza-Florido A, Esteban-Cornejo I, Mora-Gonzalez J, Torres-Lopez LV, Osuna-Prieto FJ, Gil-Cosano JJ, Radom-Aizik S, Labayen I, Ruiz JR, Altmäe S, Ortega FB. Gene-exercise interaction on brain health in children with overweight/obesity: the ActiveBrains randomized controlled trial. J Appl Physiol (1985). 135(4):775-785, 2023.
  • Plaza-Florido A, Lucia A, Radom-Aizik S. Advancing pediatric exercise research: A focus on immunomics and cutting-edge technologies. J Sport Health Sci. 2023.
  • Altmäe S, Plaza-Florido A, Esteban FJ, Anguita-Ruiz A, Krjutškov K, Katayama S, Einarsdottir E, Kere J, Radom-Aizik S, Ortega FB. Effects of exercise on whole-blood transcriptome profile in children with overweight/obesity – A Pilot Study. Am J Hum Biol. 2023.
  • Nicholas Coronato, Donald E. Brown, Yash Sharma, Ronen Bar-Yoseph, Shlomit Radom-Aizik, and Dan M. Cooper MD. Functional data analysis for predicting pediatric failure to complete ten brief exercise bouts. IEEE Journal of Biomedical and Health Informatics. 2022.
  • Matt Grant Rieger, Christine M Tallon, Dean Ryan Perkins, Mike Stembridge, Kurt Jason Smith, Sebastian Piombo, Shlomit Radom-Aizik, Dan M Cooper, Philip N Ainslie, and Ali M McManus. Cardiopulmonary and Cerebrovascular Acclimatation in Children and Adults at 3800 Meters. The Journal of Physiology, 2022.
  • Bar-Yoseph R, Radom-Aizik S, Coronato N, Moradinasab N, Barstow TJ, Stehli A, Brown D, Cooper DM. Heart Rate and Gas Exchange Dynamic Responses to Multiple Brief Exercise Bouts (MBEB) in Early and Late Pubertal Boys and Girls. Physiological Reports. 10(15):e15397, 2022.
  • Jean-G. Gehricke, Lea Ann Lowery, Sharina Dyan Alejo Meghan Dawson James Chan Robert A. Parker Abigail Archibald Angelina LoHazel Benavidez Tanya Saini Karen KuhlthauYulissa Trujillo Olivia Grigaux Samantha, Cadondon Mariel Baconawa, Katherine Bellesheim, Megan Sweeney, Fadia Haddad, Shlomit Radom-Aizik. The effects of a physical exercise program, LEGOR and Minecraft activities on anxiety in underserved children with autism spectrum disorder. Research in Autism Spectrum Disorders. Volume 97 2022.
  • Abel Plaza-Florido, Inmaculada Pérez-Prieto, Pablo Molina-Garcia, Shlomit Radom-Aizik, Francisco B. Ortega and Signe Altmäe. Transcriptional and Epigenetic Response to Sedentary Behavior and Physical Activity in Children and Adolescents: A Systematic Review. Front Pediatr. 2022.
  • Robert V. Warren, Ronen Bar-Yoseph, Brian Hill, Drew Reilly, Abraham Chiu, Shlomit Radom-Aizik, Dan M. Cooper, Bruce J. Tromberg. Diffuse optical spectroscopic method for tissue and body composition assessment. J. of Biomedical Optics. 27(6), 2022.
  • Caleb Bhatnagar, Jeet Shah, Bhumi Ramani, Abhilasha Surampalli, Mahima Avanti, Shlomit Radom-Aizik, Margaret Knight, Lan Weiss, Vince Caiozzo, Virginia Kimonis. Safety and effectiveness of resistance training in patients with late onset Pompe disease – A pilot study. Neuromuscular Disorders. 32(4):284-294, 2022.
  • Steven C. Cramer, MD, Jill See, MPT, Brent Liu, PhD, Matthew Edwardson, MD, Ximing Wang, PhD, Shlomit Radom-Aizik, PhD, Fadia Haddad, PhD, Babak Shahbaba, PhD, Steven L. Wolf, PT, PhD, Alexander W. Dromerick, MD, Carolee J. Winstein, PT, PhD. Genetic Factors, Brain Atrophy, and Response to Rehabilitation Therapy after Stroke. Neurorehabil Neural Repair. 36(2):131-139, 2022.
  • Matt Rieger, Isabel Algaze, Adriana Rodriguez-Vasquez, Kurt Smith, Mike Stembridge, Brianne Smith, Shlomit Radom-Aizik, Alison McManus. Kids With Altitude: Acute Mountain Sickness and Changes in Body Mass and Total Body Water in Children Travelling to 3800 m. Wilderness Environ Med. 33(1):33-42, 2022.
  • Dan M. Cooper, Ronen Bar-Yoseph, Robert I. Liem, Thomas G. Keens, Susanna A. McColley, Shlomit Radom-Aizik PhD. Pediatric Cardiopulmonary Exercise Testing: Interoperability Through Domain Analysis Modeling and A National Survey. Med Sci Sports Exerc. 54(5):741-750, 2022.
  • Kim Lu, Margo Sidell, Xia Li, Emily Rozema, Dan M Cooper, Shlomit Radom-Aizik, William W Crawford, Corinna Koebnick. Self-Reported Physical Activity and Asthma Risk in Children. J Allergy Clin Immunol Pract. 10(1):231-239, 2022.
  • N Dror 1, J Carbone, F Haddad, B Falk, P Klentrou, S Radom-Aizik. Sclerostin and bone turnover markers response to cycling and running at the same moderate-to-vigorous exercise intensity in healthy men. J Endocrinol Invest. 45(2):391-397, 2022.
  • Ricky Camplain, Nanette V Lopez, Dan M Cooper, Thomas L McKenzie, Kai Zheng, Shlomit Radom-Aizik. Development of the systematic observation of COVID-19 mitigation (SOCOM): Assessing face covering and distancing in schools. J Clin Transl Sci. 5(1), 2021.
  • Abel Plaza-Florido, Signe Altmäe , Francisco J Esteban 4, Marie Löf, Shlomit Radom-Aizik, Francisco B Ortega. Cardiorespiratory Fitness in Children with Overweight-Obesity: Insights into the Molecular Mechanisms. Scand J Med Sci Sports. 31(11):2083-2091, 2021.
  • Kellsey N Smith, Tracy Baynard, Peter S Fischbach, Jane S Hankins, Lewis L Hsu, Peggy M Murphy, Kiri K Ness, Shlomit Radom-Aizik, Amy Tang, Robert I Liem. Safety of maximal cardiopulmonary exercise testing in individuals with sickle cell disease: a systematic review. Br J Sports Med. 56(13):764-769, 2022.
  • Lu KD, Cooper D, Dubrowski R, Barwick M, Radom-Aizik S. Exploration of Barriers and Facilitators to Implementing Best Practice in Exercise Medicine in Primary Pediatric Care-Pediatrician Perspectives. Pediatr Exerc Sci. 33(4):162-169, 2021.
  • Dror N, Weidling J, White S, Ortenzio F, Shreim S, Keating MT, Pham H, Radom-Aizik S, Botvinick E. Clinical evaluation of a novel subcutaneous lactate monitor. J Clin Monit Comput. 36(2):537-543, 2022.
  • Neikrug AB, Mander BA, Radom-Aizik S, Chen IY, Stehli A, Lui KK, Miranda G Chappel-Farley, Abhishek Dave, Ruth M Benca. Aerobic fitness and the sleeping brain of adolescents – A pilot study. Sleep Adv. 2(1):zpab005, 2021.
  • Bartley, Jenna; Stearns, Rebecca; Munoz, Colleen; Nolan, Julie; Radom-Aizik, Shlomit; Maresh, Carl; Casa, Douglas; Zaldivar, Frank; Haddad, Fadia; Ganio, Matthew; Lee, Elaine. Effects of cold-water immersion on circulating inflammatory markers at the Kona Ironman World Championship. Appl Physiol Nutr Metab. 46(7):719-726, 2021.
  • Cooper DM, Afghani B, Byington CL, Cunningham CK, Golub S, Lu KD, Radom-Aizik S, Ross LF, Singh J, Smoyer WE, Lucas CT, Tunney J, Zaldivar F, Ulloa ER. SARS-CoV-2 vaccine testing and trials in the pediatric population: biologic, ethical, research, and implementation challenges. Pediatr Res. 24:1-5, 2021.
  • Abel Plaza-Florido, Signe Altmäe, Francisco J Esteban, Cristina Cadenas-Sanchez, Concepción M Aguilera, Elisabet Einarsdottir, Shintaro Katayama, Kaarel Krjutškov, Juha Kere, Frank Zaldivar, Shlomit Radom-Aizik, Francisco B Ortega. Distinct whole-blood transcriptome profile of children with metabolic healthy overweight/obesity compared to metabolic unhealthy overweight/obesity. Pediatr Res. 89(7):1687-1694, 2021.
  • R I Liem 1, T Baynard 2, L L Hsu 3, R Garofano 4, N S Green 5, J S Hankins 6, K K Ness 7, M Rodeghier 8, S Radom-Aizik. The Sickle Cell Pro-Inflammatory Response to Interval Testing Study (SPRINTS) in children and young adults with sickle cell anemia – Study design and methodological strategies. Contemp Clin Trials Commun. 2020.
  • Sanford JA, Nogiec CD, Lindholm ME, Adkins JN, Amar D, Dasari S, Drugan JK, Fernández FM, Radom-Aizik S, Schenk S, Snyder MP, Tracy RP, Vanderboom P, Trappe S, Walsh MJ; Molecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to Exercise. Cell. 181(7):1464-1474, 2020.
  • Lu KD, Forno E, Radom-Aizik S, Cooper DM. Low fitness and increased sedentary time are associated with worse asthma-The National Youth Fitness Survey. Pediatr Pulmonol. 55(5):1116-1123, 2020.
  • Cooper DM, Girolami GL, Kepes B, Stehli A, Lucas CT, Haddad F, Zalidvar F, Dror N, Ahmad I, Soliman A, Radom-Aizik S. Body composition and neuromotor development in the year after NICU discharge in premature infants. Pediatr Res. 88(3):459-465, 2020.
  • Cooper DM, Radom-Aizik S. Exercise-associated prevention of adult cardiovascular disease in children and adolescents: monocytes, molecular mechanisms, and a call for discovery. Pediatr Res. 2019.
  • Bar-Yoseph R, Porszasz J, Radom-Aizik S, Stehli A, Law P, Cooper DM. The effect of test modality on dynamic exercise biomarkers in children, adolescents, and young adults. Physiol Rep. 7(17):e14231, 2019.
  • Lobo-Prat J, Dong Y, Moreso G, Lew C, Sharifrazi N, Radom-Aizik S, Reinkensmeyer DJ. Development and Evaluation of MOVit: An Exercise-Enabling Interface for Driving a Powered Wheelchair. IEEE Trans Neural Syst Rehabil Eng. 27(9):1770-1779, 2019.
  • Kimberley D Lakes, Kelli Sharp, Marybeth Grant-Beuttler, Ross Neville, Fadia Haddad, Rachel Sunico, Daniel Ho, Melinda Schneider, Sofia Sawitz, Janine Paulsen, Kim Caputo, Kim Lu, Afshin Aminian, Citlali Lopez-Ortiz, Shlomit Radom-Aizik. A Six Week Therapeutic Ballet Intervention Improved Gait and Inhibitory Control in Children with Cerebral Palsy – A Pilot Study. Front. Public Health. 2019.
  • Michael Chu, Thao Nguyen, Vaibhav Pandey, Yongxiao Zhou, Hoang N. Pham, Ronen Bar-Yoseph, Shlomit Radom-Aizik, Ramesh Jain, Dan M. Cooper & Michelle Khine. Respiration rate and volume measurements using wearable strain sensors. NPJ Digital Medicine. 2:8, 2019
  • Lu KD, Cooper DM, Haddad F1, Radom-Aizik S. Four Months of a School-Based Exercise Program Improved Aerobic Fitness and Clinical Outcomes in a Low-SES Population of Normal Weight and Overweight/Obese Children With Asthma. Front Pediatr. 6:380, 2018.
  • Jen Jen Chen, Dan M. Cooper, Fadia Haddad, Anna Sladkey, Eliezer Nussbaum and Shlomit Radom-Aizik. Tele-Exercise as a Promising Tool to Promote Exercise in Children With Cystic Fibrosis. Front. Public Health. 6:269, 2018
  • Sally MB, Malinoski DJ, Zaldivar FP, Le T, Khosnevis M, Pinette T, Hutchens M, Radom-Aizik S. A Porcine Model to Study the Effect of Brain Death on Kidney Genomic Responses. Journal of Clinical and Translational Science. In Press, 2018.
  • Jajtner AR, Townsend JR, Beyer, KS, Varanoske AN, Church DD, Oliveira LP, Herrlinger K, Radom-Aizik S, Fukuda DH, Stout JR, Hoffman JR. Resistance Exercise Elicits a Selective Mobilization of Monocyte Subsets: Role of Polyphenol. Med Sci Sports Exerc, 2018.
  • Jen Jen Chen, Elizabeth Gendy, Sharon Leu, Frank Zaldivar, Pietro Gallassetti, Eliezer Nussbaum, Dan Cooper, Shlomit Random-Aizik. Age, Sex and Weight Effects on Lactate and Leukocyte Response to Exercise in Children and Adolescents. European Journal of Sports & Exercise Science. 6(1):1-4, 2018.
  • Radom-Aizik S, Zaldivar FP, Nance DM, Haddad F, Cooper DM, Adams GR. A Translational Model of Incomplete Catch-Up Growth: Early-Life Hypoxia and the Effect of Physical Activity. Clinical and translational science. 2018.
  • Lakes KD, Abdullah MM, Youssef J, Donnelly JH, Taylor-Lucas C, Goldberg WA, Cooper D, Radom-Aizik S. Assessing Parent Perceptions of Physical Activity in Families of Toddlers With Neurodevelopmental Disorders: The Parent Perceptions of Physical Activity Scale (PPPAS). Pediatr Exerc 30(2):314, 2018.
  • Lu KD, Cooper D, Haddad F, Zaldivar F, Kraft M, Radom-Aizik S. Glucocorticoid receptor expression on circulating leukocytes in healthy and asthmatic adolescents in response to exercise. Pediatric research 82(2):261-271, 2017.
  • Radom-Aizik S, Immune Response to Exercise During Growth. Pediatr Exerc Sci. 29(1):49-52, 2017.